Anti-inflammatory Actions of Praxelis Clematidea

Abstract

Praxelis clematidea is a plant species that belongs to the Asteraceae family. It is native to South America and has been traditionally used in folk medicine for its medicinal properties. Researchers have investigated the chemical constituents of Praxelis clematidea and identified several anti-inflammatory phenolics and phenylpropanoids. Here is some information about these compounds: The anti-inflammatory properties of Praxelis clematidea phenolics and phenylpropanoids make them of interest for potential therapeutic applications. Studies have identified various phenolics and phenylpropanoids in Praxelis clematidea, including flavonoids, caffeic acid derivatives, coumarins, and lignans. Some of the specific compounds reported include clematidin, clematomandshurin, clematoside-I, clematoside-II, and praxelin. Liang and his colleagues have demonstrated the anti-inflammatory activity of these compounds. They have been shown to inhibit the production of pro-inflammatory molecules, such as nitric oxide (NO), prostaglandin E2 (PGE2), and pro-inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). They can inhibit the activation of transcription factors like nuclear factor-kappa B (NF-κB) and activator protein-1 (AP-1), which are key regulators of inflammatory responses. The authors concluded that given their anti-inflammatory properties, the phenolics and phenylpropanoids from Praxelis clematidea have the potential for use in the development of natural anti-inflammatory agents or as leads for drug discovery targeting inflammation-related conditions. Fitoterapia. 2023 Jun;167:105476.  doi: 10.1016/j.fitote.2023.105476.