Targeting the Endocannabinoid System

Abstract

Metabolism, inflammation, neural development, neuronal excitation, and cell division are some of the many biochemical functions in which endocannabinoid system is significantly involved. 9-tetrahydrocannabinol (THC) and cannabidiol (CBD), which are important phytocompounds found in Cannabis sativa, have demonstrated the ability to target the endocannabinoid system. The potential therapeutic applications of both phyto- and synthetic cannabinoids as well as their mechanisms have been explained in a study by Keimpema and colleagues. In spite of the fact that there are promising results for endocannabinoid modulation in certain kinds of epilepsy, there is significantly more that has to be perceived about the potential role of phytocannabinoids and their targets before they can be considered efficacious and safe therapeutics. Science. 2021 Dec 17;374(6574):1449-1450.