Blood Direct PCR for Detection of CYP2C19 and CYP4F2 Variants

Abstract

Tatarunas et al, intended to develop and introduce into clinical practice a technique that can rapidly determine CYP2C19 rs4244285 and CTP4F2 rs3093135 genotypes from blood samples of patients. They recruited 144 consecutive patients with ST-elevated myocardial infarction for their study. Real-time PCR and Blood-direct PCR were performed to identify the variants. Their results show that CYP2C19 GG (*1*1) was more common in patients with an increased frequency of bleeding events. Patients who still had bleeding problems after 3 months of hospitalization had a higher frequency of the CYP4F2 TT variant. Per Med. 2022 May;19(3):207-217.